The interior design of Comfort Hotel Grand Central is grounded both in the history of the building (parts of which are heritage-protected) and in a utilitarian aesthetic designed to appeal to the creative class. Varying greatly in shape and size, the building's 170 hotel rooms are furnished in a spare, urban style highlighted with lived-in, heirloom elements.

Artwork by Ariel McMillion appears in 158 rooms, and 57 bathroom niches, as well as in elevators and public spaces, and on signs throughout the building.

This video has been been used for several years, by the artist, to showcase his work on the Hotel.